AustralieFrV1, Main, Exploration, bibRecord, 00A675

Durable efficacy of enfuvirtide over 48 weeks in heavily treatment-experienced HIV-1-infected patients in the T-20 versus optimized background regimen only 1 and 2 clinical trials

Identifieur interne : 00A675 ( Main/Exploration ); précédent : 00A674; suivant : 00A676

Durable efficacy of enfuvirtide over 48 weeks in heavily treatment-experienced HIV-1-infected patients in the T-20 versus optimized background regimen only 1 and 2 clinical trials

Auteurs : Mark Nelson [Royaume-Uni] ; Keikawus Arasteh [Allemagne] ; Bonaventura Clotet [Espagne] ; David A. Cooper [Australie] ; Keith Henry [États-Unis] ; Christine Katlama [France] ; Jacob P. Lalezari [États-Unis] ; Adriano Lazzarin [Italie] ; Julio S. G. Montaner [Canada] ; Mary O'Hearn [États-Unis] ; Peter J. Piliero [États-Unis] ; Jacques Reynes [France] ; Benoit Trottier [Canada] ; Sharon L. Walmsley [Canada] ; Calvin Cohen [États-Unis] ; Joseph J. Jr Eron [États-Unis] ; Daniel R. Kuritzkes [États-Unis] ; Joep Lange [Pays-Bas] ; Hans-Jürgen Stellbrink [Allemagne] ; Jean-Francois Delfraissy [France] ; Neil E. Buss [Suisse] ; Lucille Donatacci [États-Unis] ; Cynthia Wat [Royaume-Uni] ; Lynn Smiley [États-Unis] ; Martin Wilkinson [Royaume-Uni] ; Adeline Valentine [États-Unis] ; Denise Guimaraes [États-Unis] ; Ralph Demasi [Royaume-Uni] ; Jain Chung [États-Unis] ; Miklos P. Salgo [États-Unis]

Source :

Journal of acquired immune deficiency syndromes : (1999) [ 1525-4135 ] ; 2005.

RBID : Pascal:06-0030547

Descripteurs français

Pascal (Inist)
- Virus immunodéficience humaine, Efficacité, Traitement, Essai clinique, Microbiologie, Virologie, Enfuvirtide, SIDA.

English descriptors

KwdEn :
- AIDS, Clinical trial, Efficiency, Enfuvirtide, Human immunodeficiency virus, Microbiology, Treatment, Virology.

Abstract

Background: The T-20 Versus Optimized Background Regimen Only (TORO) 1 and TORO 2 clinical trials are open-label, controlled parallel-group, phase 3 studies comparing enfuvirtide plus an optimized background (OB) of antiretrovirals (n = 661) with OB alone (n = 334) in treatment-experienced HIV-1-infected patients. Methods: The primary objective at week 48 was to investigate durability of efficacy, as measured by the percentage of patients maintaining their week 24 response or improving. Efficacy analyses used the intent-to-treat population. Results: A total of 73.7% of patients randomized to the enfuvirtide group remained on treatment through week 48 versus 21.3% originally randomized to the control group. At week 48, a higher proportion of week 24 responders maintained their response or were new responders in the enfuvirtide group than in the control group in each responder category: HIV-1 RNA level ≥1.0 log₁₀ change from baseline, <400 copies/mL and <50 copies/mL (37.4%, 30.4%, and 18.3% in the enfuvirtide group vs. 17.1%, 12.0%, and 7.8% in the control group, respectively; P < 0.0001 for all comparisons). CD4 cell count increases from baseline were twice as great in the enfuvirtide group as in the control group. Conclusion: These data demonstrate durable efficacy of enfuvirtide plus OB over 48 weeks.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Durable efficacy of enfuvirtide over 48 weeks in heavily treatment-experienced HIV-1-infected patients in the T-20 versus optimized background regimen only 1 and 2 clinical trials</title>
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</author>
<author><name sortKey="Clotet, Bonaventura" sort="Clotet, Bonaventura" uniqKey="Clotet B" first="Bonaventura" last="Clotet">Bonaventura Clotet</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hospital Universitari Germans Trias i Pujol and Institut de Recerca de la SIDA-Caixa Foundation</s1>
<s2>Badalona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Hospital Universitari Germans Trias i Pujol and Institut de Recerca de la SIDA-Caixa Foundation</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>National Centre in HIV Epidemiology and Clinical Research, Universiy of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Henry, Keith" sort="Henry, Keith" uniqKey="Henry K" first="Keith" last="Henry">Keith Henry</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>HIV Program, Ilennepin County Medical Center</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Katlama, Christine" sort="Katlama, Christine" uniqKey="Katlama C" first="Christine" last="Katlama">Christine Katlama</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Serivce des Maladies Infectieuses et Tropicales. Hôpital Pitié Salpêtnère</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lalezari, Jacob P" sort="Lalezari, Jacob P" uniqKey="Lalezari J" first="Jacob P." last="Lalezari">Jacob P. Lalezari</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Quest Clinical Research</s1>
<s2>San Francisco, CA</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Quest Clinical Research</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lazzarin, Adriano" sort="Lazzarin, Adriano" uniqKey="Lazzarin A" first="Adriano" last="Lazzarin">Adriano Lazzarin</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>IRCCs, San Raffaele Vita-Salute University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montaner, Julio S G" sort="Montaner, Julio S G" uniqKey="Montaner J" first="Julio S. G." last="Montaner">Julio S. G. Montaner</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>University of British Colombia</s1>
<s2>Vancouver, British Columbia</s2>
<s3>CAN</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>University of British Colombia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Hearn, Mary" sort="O Hearn, Mary" uniqKey="O Hearn M" first="Mary" last="O'Hearn">Mary O'Hearn</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Oregon Health and Science University, School of Medicine</s1>
<s2>Portland, OR</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Portland, OR</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Piliero, Peter J" sort="Piliero, Peter J" uniqKey="Piliero P" first="Peter J." last="Piliero">Peter J. Piliero</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Boehringer Ingelheim Pharmaceuticals, Inc</s1>
<s2>Ridgefield, CT</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Ridgefield, CT</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reynes, Jacques" sort="Reynes, Jacques" uniqKey="Reynes J" first="Jacques" last="Reynes">Jacques Reynes</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Hôpital Gul dc Chauliac</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trottier, Benoit" sort="Trottier, Benoit" uniqKey="Trottier B" first="Benoit" last="Trottier">Benoit Trottier</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Clinique Médicale l'Actuel</s1>
<s2>Montréal, Quebec</s2>
<s3>CAN</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Clinique Médicale l'Actuel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Walmsley, Sharon L" sort="Walmsley, Sharon L" uniqKey="Walmsley S" first="Sharon L." last="Walmsley">Sharon L. Walmsley</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>University Health Network. University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>University Health Network. University of Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cohen, Calvin" sort="Cohen, Calvin" uniqKey="Cohen C" first="Calvin" last="Cohen">Calvin Cohen</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Community Research Initiative of New England</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Community Research Initiative of New England</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eron, Joseph J Jr" sort="Eron, Joseph J Jr" uniqKey="Eron J" first="Joseph J. Jr" last="Eron">Joseph J. Jr Eron</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>University of North Carolina at Chapel Hill School of Medicine</s1>
<s2>Chapel Hill, NC</s2>
<s3>USA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of North Carolina at Chapel Hill School of Medicine</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kuritzkes, Daniel R" sort="Kuritzkes, Daniel R" uniqKey="Kuritzkes D" first="Daniel R." last="Kuritzkes">Daniel R. Kuritzkes</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Section of Retroviral Therapeutics, Brigham and Women's Hospital and Harvard Medical School</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lange, Joep" sort="Lange, Joep" uniqKey="Lange J" first="Joep" last="Lange">Joep Lange</name>
<affiliation wicri:level="4"><inist:fA14 i1="18"><s1>Acadciuic Medical Center, University of Amsterdam</s1>
<s2>Amsterdam</s2>
<s3>NLD</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author><name sortKey="Stellbrink, Hans Jurgen" sort="Stellbrink, Hans Jurgen" uniqKey="Stellbrink H" first="Hans-Jürgen" last="Stellbrink">Hans-Jürgen Stellbrink</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>University Hospital Eppendorf</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delfraissy, Jean Francois" sort="Delfraissy, Jean Francois" uniqKey="Delfraissy J" first="Jean-Francois" last="Delfraissy">Jean-Francois Delfraissy</name>
<affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Hôpital Bicêtre</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buss, Neil E" sort="Buss, Neil E" uniqKey="Buss N" first="Neil E." last="Buss">Neil E. Buss</name>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Roche</s1>
<s2>Basel</s2>
<s3>CHE</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>Roche</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Donatacci, Lucille" sort="Donatacci, Lucille" uniqKey="Donatacci L" first="Lucille" last="Donatacci">Lucille Donatacci</name>
<affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Roche</s1>
<s2>Nutley, NJ</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Roche</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wat, Cynthia" sort="Wat, Cynthia" uniqKey="Wat C" first="Cynthia" last="Wat">Cynthia Wat</name>
<affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Roche</s1>
<s2>Welwyn</s2>
<s3>GBR</s3>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Roche</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smiley, Lynn" sort="Smiley, Lynn" uniqKey="Smiley L" first="Lynn" last="Smiley">Lynn Smiley</name>
<affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Trimeris</s1>
<s2>Morrisville, NC</s2>
<s3>USA</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Trimeris</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wilkinson, Martin" sort="Wilkinson, Martin" uniqKey="Wilkinson M" first="Martin" last="Wilkinson">Martin Wilkinson</name>
<affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Roche</s1>
<s2>Welwyn</s2>
<s3>GBR</s3>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Roche</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Valentine, Adeline" sort="Valentine, Adeline" uniqKey="Valentine A" first="Adeline" last="Valentine">Adeline Valentine</name>
<affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Roche</s1>
<s2>Nutley, NJ</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Roche</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guimaraes, Denise" sort="Guimaraes, Denise" uniqKey="Guimaraes D" first="Denise" last="Guimaraes">Denise Guimaraes</name>
<affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Roche</s1>
<s2>Nutley, NJ</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Roche</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demasi, Ralph" sort="Demasi, Ralph" uniqKey="Demasi R" first="Ralph" last="Demasi">Ralph Demasi</name>
<affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Roche</s1>
<s2>Welwyn</s2>
<s3>GBR</s3>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Roche</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chung, Jain" sort="Chung, Jain" uniqKey="Chung J" first="Jain" last="Chung">Jain Chung</name>
<affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Roche</s1>
<s2>Nutley, NJ</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Roche</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salgo, Miklos P" sort="Salgo, Miklos P" uniqKey="Salgo M" first="Miklos P." last="Salgo">Miklos P. Salgo</name>
<affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Roche</s1>
<s2>Nutley, NJ</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Roche</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of acquired immune deficiency syndromes : (1999)</title>
<title level="j" type="abbreviated">J. acquir. immune defic. syndr. : (1999)</title>
<idno type="ISSN">1525-4135</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of acquired immune deficiency syndromes : (1999)</title>
<title level="j" type="abbreviated">J. acquir. immune defic. syndr. : (1999)</title>
<idno type="ISSN">1525-4135</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Clinical trial</term>
<term>Efficiency</term>
<term>Enfuvirtide</term>
<term>Human immunodeficiency virus</term>
<term>Microbiology</term>
<term>Treatment</term>
<term>Virology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus immunodéficience humaine</term>
<term>Efficacité</term>
<term>Traitement</term>
<term>Essai clinique</term>
<term>Microbiologie</term>
<term>Virologie</term>
<term>Enfuvirtide</term>
<term>SIDA</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: The T-20 Versus Optimized Background Regimen Only (TORO) 1 and TORO 2 clinical trials are open-label, controlled parallel-group, phase 3 studies comparing enfuvirtide plus an optimized background (OB) of antiretrovirals (n = 661) with OB alone (n = 334) in treatment-experienced HIV-1-infected patients. Methods: The primary objective at week 48 was to investigate durability of efficacy, as measured by the percentage of patients maintaining their week 24 response or improving. Efficacy analyses used the intent-to-treat population. Results: A total of 73.7% of patients randomized to the enfuvirtide group remained on treatment through week 48 versus 21.3% originally randomized to the control group. At week 48, a higher proportion of week 24 responders maintained their response or were new responders in the enfuvirtide group than in the control group in each responder category: HIV-1 RNA level ≥1.0 log<sub>10</sub>
 change from baseline, <400 copies/mL and <50 copies/mL (37.4%, 30.4%, and 18.3% in the enfuvirtide group vs. 17.1%, 12.0%, and 7.8% in the control group, respectively; P < 0.0001 for all comparisons). CD4 cell count increases from baseline were twice as great in the enfuvirtide group as in the control group. Conclusion: These data demonstrate durable efficacy of enfuvirtide plus OB over 48 weeks.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Berlin</li>
<li>Grand Londres</li>
<li>Hambourg</li>
<li>Hollande-Septentrionale</li>
<li>Languedoc-Roussillon</li>
<li>Lombardie</li>
<li>Nouvelle-Galles du Sud</li>
<li>Occitanie (région administrative)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Amsterdam</li>
<li>Berlin</li>
<li>Hambourg</li>
<li>Londres</li>
<li>Milan</li>
<li>Montpellier</li>
<li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université d'Amsterdam</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Nelson, Mark" sort="Nelson, Mark" uniqKey="Nelson M" first="Mark" last="Nelson">Mark Nelson</name>
</region>
<name sortKey="Demasi, Ralph" sort="Demasi, Ralph" uniqKey="Demasi R" first="Ralph" last="Demasi">Ralph Demasi</name>
<name sortKey="Wat, Cynthia" sort="Wat, Cynthia" uniqKey="Wat C" first="Cynthia" last="Wat">Cynthia Wat</name>
<name sortKey="Wilkinson, Martin" sort="Wilkinson, Martin" uniqKey="Wilkinson M" first="Martin" last="Wilkinson">Martin Wilkinson</name>
</country>
<country name="Allemagne"><region name="Berlin"><name sortKey="Arasteh, Keikawus" sort="Arasteh, Keikawus" uniqKey="Arasteh K" first="Keikawus" last="Arasteh">Keikawus Arasteh</name>
</region>
<name sortKey="Stellbrink, Hans Jurgen" sort="Stellbrink, Hans Jurgen" uniqKey="Stellbrink H" first="Hans-Jürgen" last="Stellbrink">Hans-Jürgen Stellbrink</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Clotet, Bonaventura" sort="Clotet, Bonaventura" uniqKey="Clotet B" first="Bonaventura" last="Clotet">Bonaventura Clotet</name>
</noRegion>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name>
</region>
</country>
<country name="États-Unis"><noRegion><name sortKey="Henry, Keith" sort="Henry, Keith" uniqKey="Henry K" first="Keith" last="Henry">Keith Henry</name>
</noRegion>
<name sortKey="Chung, Jain" sort="Chung, Jain" uniqKey="Chung J" first="Jain" last="Chung">Jain Chung</name>
<name sortKey="Cohen, Calvin" sort="Cohen, Calvin" uniqKey="Cohen C" first="Calvin" last="Cohen">Calvin Cohen</name>
<name sortKey="Donatacci, Lucille" sort="Donatacci, Lucille" uniqKey="Donatacci L" first="Lucille" last="Donatacci">Lucille Donatacci</name>
<name sortKey="Eron, Joseph J Jr" sort="Eron, Joseph J Jr" uniqKey="Eron J" first="Joseph J. Jr" last="Eron">Joseph J. Jr Eron</name>
<name sortKey="Guimaraes, Denise" sort="Guimaraes, Denise" uniqKey="Guimaraes D" first="Denise" last="Guimaraes">Denise Guimaraes</name>
<name sortKey="Kuritzkes, Daniel R" sort="Kuritzkes, Daniel R" uniqKey="Kuritzkes D" first="Daniel R." last="Kuritzkes">Daniel R. Kuritzkes</name>
<name sortKey="Lalezari, Jacob P" sort="Lalezari, Jacob P" uniqKey="Lalezari J" first="Jacob P." last="Lalezari">Jacob P. Lalezari</name>
<name sortKey="O Hearn, Mary" sort="O Hearn, Mary" uniqKey="O Hearn M" first="Mary" last="O'Hearn">Mary O'Hearn</name>
<name sortKey="Piliero, Peter J" sort="Piliero, Peter J" uniqKey="Piliero P" first="Peter J." last="Piliero">Peter J. Piliero</name>
<name sortKey="Salgo, Miklos P" sort="Salgo, Miklos P" uniqKey="Salgo M" first="Miklos P." last="Salgo">Miklos P. Salgo</name>
<name sortKey="Smiley, Lynn" sort="Smiley, Lynn" uniqKey="Smiley L" first="Lynn" last="Smiley">Lynn Smiley</name>
<name sortKey="Valentine, Adeline" sort="Valentine, Adeline" uniqKey="Valentine A" first="Adeline" last="Valentine">Adeline Valentine</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Katlama, Christine" sort="Katlama, Christine" uniqKey="Katlama C" first="Christine" last="Katlama">Christine Katlama</name>
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<name sortKey="Delfraissy, Jean Francois" sort="Delfraissy, Jean Francois" uniqKey="Delfraissy J" first="Jean-Francois" last="Delfraissy">Jean-Francois Delfraissy</name>
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   |texte=   Durable efficacy of enfuvirtide over 48 weeks in heavily treatment-experienced HIV-1-infected patients in the T-20 versus optimized background regimen only 1 and 2 clinical trials
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

Durable efficacy of enfuvirtide over 48 weeks in heavily treatment-experienced HIV-1-infected patients in the T-20 versus optimized background regimen only 1 and 2 clinical trials

Durable efficacy of enfuvirtide over 48 weeks in heavily treatment-experienced HIV-1-infected patients in the T-20 versus optimized background regimen only 1 and 2 clinical trials

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